Call for Proposals for Research Projects on "Synaptic Dysfunction in Disorders of the Central Nervous System"

This call has been closed.

The aim of the call is to facilitate multinational, collaborative research projects that will address important questions related to the synaptic dysfunction of the central nervous system. Defective synaptic communication is at the origin of numerous neurological and mental disorders synaptopathies - such as epilepsies, migraine, autism spectrum disorders, schizophrenia, mood disorders and others. The synaptopathies are often characterized by common alterations of proteins and molecular pathways affecting either neurons or glia at synapses and altering pre- and/or post-synaptic function. The present call will accept proposals addressing the disease-related synaptic dysfunction with approaches ranging from understanding basic mechanisms of disease through proof-of-concept therapeutically-driven clinical studies in humans.

Research proposals should cover at least one of the following areas:

a) Fundamental research on the pathogenesis and/or aetiology of synaptopathies. This may include the development of innovative or shared resources and new technologies for prevention, diagnosis or therapy of disease.

b) Clinical research, including the exploitation of existing clinical data sets, to develop new strategies for prevention, diagnosis, and therapy for diseases in which synaptic dysfunction plays a key role.

The research proposals should focus on common neurological and mental disorders or cross-disease approaches. They may encompass the entire lifespan.

The individual components of joint applications should be complementary and contain novel, ambitious ideas to answer key questions or lead to a step-wise change in understanding. There should be a clear added value in funding the collaboration over the individual projects.

Clinical studies up to the point of proof of concept are eligible for funding.

Excluded from this call are research projects focused on:

1) Peripheral nervous system diseases,

2) Purely basic research projects focused on synaptic function without a clear objective of addressIng the synaptic dysfunction in the context of neurological and mental disorders,

3) Primarily neurodegenerative disorders, since they are addressed by the “EU Joint Programme - Neurodegenerative Disease Research (JPND)


Proposal submission: It is strongly recommended that all applicants thoroughly read the information provided below.


Call text: Read more about this call’s purpose, aims, and application procedures.

Country-specific information: Please study thoroughly the regulations for your country/region

Contact persons: It is strongly recommended that applicants call their national/regional contact person prior to submitting a proposal.

Pre-proposal template and online submission: Please download the pre-proposal template and find the link for the pre-proposal submission here.


For general information, please contact the Joint Call Secretariat:

ERA-NET NEURON Joint Call Secretariat
National Institute of Health Carlos III (ISCIII)
Maria Druet
Phone: +34 918 222530